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Tremor-related neuronal activity in globus pallidus internus in parkinsonian patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1001-2346.2002.01.006
- Key Word:
- 帕金森病;震颤;苍白球毁损术;震颤细胞;立体定向
Abstract： 目的探讨帕金森病(PD)特征性震颤与内苍白球(GPi)神经元电活动的关系,指导手术靶点的精确定位.方法 10例PD患者接受了立体定向苍白球腹后部毁损术,术中应用微电极和肌电(EMG)记录技术,采集GPi神经元和肢体震颤的生物电活动.术后应用分析软件甄别单细胞及其电活动特点,分析其与震颤症状的关系,并进行相关性检验.结果在GPi共记录到了112个神经元,有57个(51%)震颤细胞,且主要分布在视束上方4～6mm,其簇状放电的节律与肢体震颤的节律高度一致(4～6Hz),R2=0.71(P＜0.01).毁损震颤细胞导致震颤症状的消失.结论震颤型PD患者的GPi存在电活动与肢体震颤节律一致的震颤细胞.该细胞的发现和定位,对于指导手术毁损的部位和范围具有重要意义.
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