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Subthalamic nucleus stimulation for parkinson's disease
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1001-2346.2002.01.005
- Key Word:
- 帕金森病;丘脑底核;深部脑刺激;立体定向
Abstract： 目的研究脑深部电刺激(DBS)对帕金森病(PD)的治疗作用,观察术中丘脑底核(STN)刺激对PD震颤、肌僵直、运动缓慢的缓解效果以及对语言的影响,探讨电极在丘脑底核内的解剖位置与刺激效果的关系,以寻找植入刺激电极至STN的最佳位置.方法 26例帕金森病患者,利用MRI及微电极导向立体定向方法将刺激电极植入丘脑底核,其靶点:X＝11mm～13mm,Y=-1mm～-3mm,Z=-7mm.术中予以高频刺激(频率为130Hz～150Hz,脉宽为90μs～150μs,电压自0.5V开始,逐渐增至8V);利用电极的不同触点分别进行刺激,根据刺激效果和副反应的出现情况,确定电极在STN中的最佳位置.其中有3例进行了STN电极永久性植入,术后随访6～14月.结果 26例术中刺激发现,STN背外侧部是电刺激的最佳位置,而电极过深及过外则易引起言语障碍.结论 STN的高频刺激能改善PD的震颤、僵直、运动缓慢等主要症状,是PD慢性刺激的最理想靶点,其背外侧部是刺激效果的最佳位置.
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