You Position: Home > Paper
The total homocysteine concentration in the patients with ischemic stroke or carotid atherosclerosis disease, and intervention study
( views:256, downloads:8 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1001-2346.2001.05.004
- Key Word:
- 脑梗塞;颈动脉疾病;高半胱氨酸;叶酸;维生素B12
Abstract： 目的了解正常老年人、颈动脉硬化患者及脑梗死患者血清总同型半胱氨酸(serum total homocysteine,tHcy)水平及给予叶酸和维生素B12治疗后血tHcy含量的变化.方法脑梗死组80例,男71例,女9例,年龄63～80岁,平均74岁,符合脑梗死的诊断标准,均在发病后2周内测定tHcy含量;颈动脉硬化组80例,男71例,女9例,年龄62～79岁,平均72岁 .双侧颈动脉B超检查均存在颈动脉硬化及(或)粥样斑块.以上两组均除外甲状腺功能减退及肾功能减退.正常老年人组80名,男72名,女8名,年龄61～78岁,平均71岁,符合健康老年人的诊断标准.入选者在测定血清叶酸、维生素B12、肌酐、血糖、血脂水平及血压和体重指数后,各组均随机分成2组,即干预治疗组及非干预治疗组,每组40例.干预治疗组患者给予叶酸1.25 mg,隔日1次, 维生素B12 8 μg,每日1次,口服10个月后复查上述各项指标.结果治疗前三组血tHcy水平各不相同,脑梗死组为(16.1±5.3)μmol/L,颈动脉硬化组为(14.2±4.7) μmol/L,正常老年人组为(12.5±3.0) μmol/L,三组比较差异有显著意义.血tHcy含量越高,叶酸水平越低.相关分析发现,血tHcy水平与叶酸、维生素B12呈负相关.干预治疗后,治疗组患者的血tHcy含量均有下降.结论不同程度的脑缺血性疾病与血tHcy水平有一定的关系,补充营养元素有助于降低血tHcy水平,以减少高tHcy对血管的毒性作用.
- [1]Lindgren A.,Brattstrom L.,Norrving B.,etc.Plasma Homocysteine in the Acute and Convalescent Phases After Stroke[J].1995.
- [2]Robinson K.,Arheart K.,Refsum H.,etc.Low Circulating Folate and Vitamin B6 Concentrations: Risk Factors for Stroke, Peripheral Vascular Disease, and Coronary Artery Disease[J].1998.
- [3]Hankey GJ,Eikelboom JW,Lofthouse E,etc.Association between high homocyst(e)ine and ischemic stroke due to large- and small-artery disease but not other etiologic subtypes of ischemic stroke.[J].2000,31(5).
- [4]Willinek WA,Lennarz M,Ludwig M,etc.High-normal serum homocysteine concentrations are associated with an increased risk of early atherosclerotic carotid artery wall lesions in healthy subjects.[J].2000,18(4).
- [5]S, Evers,H G, Koch,K H, Grotemeyer,etc.Features, symptoms, and neurophysiological findings in stroke associated with hyperhomocysteinemia.[J].1997,54.
- [6]Ebrahim SB,Perry IJ,Morris RW,etc.Prospective study of serum total homocysteine concentration and risk of stroke in middle-aged British men.[J].1995,346(8987).
- [7]Atsushi Araki,Yoshiyasu Sako,Yutaka Fukushima,etc.Plasma sulfhydryl-containing amino acids in patients with cerebral infarction and in hypertensive subjects[J].1989,79(2-3).