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Neuroelectrophysiological study on effect of Naloxone on acute moderate and severe head injuries
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1001-2346.2001.03.005
- Key Word:
- 纳洛酮;诱发电位;脑外伤
Abstract： 目的通过诱发电位(EP)监测,探讨金尔伦(盐酸纳洛酮)治疗急性中、重型脑外伤的疗效.方法对40例急性中、重型脑外伤患者进行随机、双盲治疗.前3天剂量为每日0.3mg/kg,后7天剂量为4.8mg/日,于用药前、用药后30分钟、24小时、72小时、120小时监测正中神经短潜伏期体感诱发电位(SLSEP)和脑干听觉诱发电位(BAEP).揭盲后分为金尔伦治疗组和对照组,对金尔伦治疗组与对照组诱发电位进行统计学分析.结果金尔伦治疗组SLSEP的N13-N20峰间潜伏期(N13-N20IPL)及BAEP的I-V波峰间潜伏期(I-VIPL)在用药后均较对照组缩短且有显著性差异,P＜0.05.结论诱发电位监测结果表明:金尔伦能有效改善急性脑外伤患者异常的神经电生理指标,对于急性中、重型脑外伤有明显的治疗作用.
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