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Clinical study of Naloxone in treatment of severe craniocerebral trauma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1001-2346.2001.03.004
- Key Word:
- 纳洛酮;颅脑损伤;阿片肽;β-内啡肽
Abstract： 目的针对重度颅脑外伤后血浆、脑脊液和脑区内源性阿片肽,特别是β-内啡肽明显升高,应用金尔伦(盐酸纳洛酮)探讨对重症颅脑外伤的临床疗效.方法选择GCS5～8分患者30例每天应用金尔伦4.8毫克,随机以30例同等伤情未用金尔伦药物治疗病例为对照组.观察意识觉醒,血液流变学及临床征象.结果觉醒天数缩短,外伤后脑血管痉挛发生率,血液粘滞度降低,致残率减少.结论金尔伦对于内源性阿片肽引起的生理功能的应激性疾病起效快、作用可靠,其使用安全,治疗过程中未见有毒副作用.
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