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The effect of Naloxone on the content of Ca2+、Mg2+、EAA in brain tissue and ET in plasma after head injury.
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF NEUROSURGERY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1001-2346.2001.03.003
- Key Word:
- 重型头伤 脑组织 Ca2+ Mg2+ EAA ET 纳洛酮
Abstract： 目的探讨金尔伦(盐酸纳洛酮)对重型头伤后脑组织内Ca2+、Mg2+、EAA及血浆ET变化的影响及临床意义.方法 SD大鼠72只,随机分为治疗组、对照组及空白组.参照Feeny自由落体撞击法建立头伤模型,伤后半小时,治疗组大鼠于腹腔注射金尔伦10mg/kg;对照组大鼠则于腹腔注射生理盐水10mg/kg;空白组不作任何处理.按伤后处理时间各组再分为4小组,每组6只,分别于伤后1小时,2小时,4小时,8小时处死1小组,检测损伤区脑组织内Ca2+、Mg2+、EAA及ET含量.结果治疗组伤后Ca2+、EAA和ET含量轻度升高,Mg2+含量下降不明显,与对照组相比有统计学差异.结论金尔伦通过竞争性拮抗内源性阿片肽受体,能明显逆转实验动物重型头伤后损伤区脑组织内Ca2+、EAA和ET含量的增高及Mg2+的下降,具有脑保护作用.其详细机理有待进一步研究.
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