Abstract： Objective　To characterize the diagnosis and treatment of gliomatosis cerebri (GC). Methods　Clinical studies of 13 patients with GC (1982-1997) were reviewed retrospectively. Results　The main clinical presentation of the 13 cases included headache (11/13), seizure (4/13), and sign of evaluated intracranial pressure later. The tumor involved at least 2 lobes of brain in all patients, in which diffused infiltration in 6 cases and multiple lesions in 7 cases. Nine cases underwent partially surgical removal of the tumor lesions and 3 cases underwent stereotactic biopsy. The Pathologic diagnosis were low-grade astrocytoma (grade Ⅰ～Ⅱ) in 11, grade I oligodendrocytoma in 1, and both mixture in 1. The mean lifetime was 5.75 months. Conclusions　The tumorigenesis, clinical presentation, characters of CT and MRI images, pathological classification, therapy and prognosis of GC were discussed.