You Position: Home > Paper

Application of Rituxnab in antibody-mediated rejection among renal transplantation recipients

( views:510, downloads:160 )
Author:
No author available
Journal Title:
Chinese Journal of Organ Transplantation
Issue:
9
DOI:
10.3760/cma.j.issn.0254-1785.2011.09.006
Key Word:
肾移植;移植物排斥;抗体;利妥昔单抗;Kidney transplantation;Graft rejection;Antibodies;Rituximab

Abstract: Objective To observe the indication, safety and efficacy of a new immunosuppressant Rituximab in kidney transplantation. Methods Five patients, who were diagnosed as antibody mediated rejection (AMR) from December 2010 to June 2011, were treated with single dose of Rituximab (500 mg) and followed up for 6 months. The clinical data, such as age, gender, onset of illness, induction therapy, maintaining therapy, allograft function, change of PRA, opportunistic infection and other complications were collected and retrospectively analyzed to evaluate the safety and efficacy of Rituximab used in AMR patients. Results After Rituximab therapy, all the patients had improved renal function measured by sera creatinine level: 4 cases retumed to normal, and 1 keep stable. Series of allograft biopsy demonstrated obviously reduced C4d deposition in nephridial tissue after treatment. One patient developed CMV viremia, another had urinary infection, but no one had lifethreatening infection during the follow-up period. The survival rate of human and allograft was both 100 %. Conclusion Rituximab has a good efficacy and safety in treatment of AMR after renal transplantation.

WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn