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A prospective, randomized, controlled clinical trial of the effects of ursodeoxycholic acid alleviating ischemia/reperfusion injury in liver transplantation

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
Issue:
3
DOI:
10.3760/cma.j.issn.0254-1785.2008.03.001
Key Word:
熊去氧胆酸;肝移植;再灌注损伤;Ursodeoxycholic acid;Liver transplantation;Reperfusion injury

Abstract: Objective To investigate the effects of ursodeoxycholic acid(UDCA)alleviating ischemia/reperfusion injury(IRI)in liver transplantation. Methods Eighty adult patients with endstage liver diseases were randomly divided into two groups:UIXTA group(n=42)in which UDCA 38)in which UDCA was not administered.The two groups were statistically compared in liver biochemical parameters,rate of severe IRI-induced graft dysfunction,acute cellular rejection(ACR)episodes,drug-induced hepatotoxicity,viral hepatitis and recurrence of primary liver disease within posttransplant 3 weeks as well as rate of vascular,biliary complications and death within post-transplant 3 months.Results Warm ischemia time(WIT)and cold ischemia time(CIT)in UDCA group were respectively(3.33±0.92)min and(10.3±1.9)h,and those in control group were(3.68±1.16)min and(9.8±2.4)h.There were no significant differences in these two parameters between the two groups.In UDCA group,serum ALT levels on post-transplant day 7,14,21 were significantly lower than those in control group(P<0.05),and compared with control group,serum levels of AST and γ-GT on day 7 were also lower in UDCA group(P<0.05).The cases of severe IRI-induced graft dysfunction in UDCA group were fewer than those in control group with the difference being significant (9.5 % vs. 26.3 %,P<0.05).There were no significant difference between the two groups in rate of ACR episode,drug-induced hepatotoxicity within post-transplant 3 weeks as well as rate of vascu lar,biliary complications and death within post-transplant 3 months.Conclusion UDCA treatment can alleviate graft IRI early after liver transplantation. It significantly decreased incidence of severe IRI-induced graft dysfunction.Protective effects of bile duct by UIX2A were not shown when CIT was beneath 12 h.

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