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Clinical analysis of the recurrence of Hepatitis B Virus-associated hepatocellular carcinoma after the orthotopic liver transplantation
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.0254-1785.2007.12.005
- Key Word:
- 肝移植;肝炎,乙型,慢性;肿瘤复发
Abstract： 目的 探讨与乙型肝炎病毒(HBV)相关的原发性肝细胞癌(HCC)患者在肝移植术后肿瘤复发与乙型肝炎复发之间的相关关系.方法 以52例与HBV相关的HCC患者为研究对象,回顾性分析这些患者的临床资料,根据肝移植后有无肿瘤复发,将患者分为肿瘤复发组(12例)和无肿瘤复发组(40例).探讨两组间临床和病理特征的差异.结果 在肿瘤复发组中,有10例患者的血清HBV表面抗体(抗-HBs)消失,其中4例在随访期间未发现HBV表面抗原(HBsAg)转阳,6例出现HBV表面抗原转阳.这6例患者首先表现为血清HBV免疫球蛋白(HBIg)药物浓度明显下降或消失,继而出现抗-HBs转阴,HBsAg转阳,2例患者的HBV-DNA复制呈阳性.而同期无肿瘤复发组的40例患者抗-HBs呈阳性,无HBsAg转阳.结论 肝癌细胞染色体中存在整合的HBV-DNA,随着转移性肝癌细胞的增殖,HBV大量复制,最终出现乙型肝炎复发.
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