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Effect of donor's activating KIR on prognosis after haemopoietic stem cell transplantation
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 8
- DOI:
- 10.3760/cma.j.issn.0254-1785.2006.08.005
- Key Word:
- 杀伤细胞;造血干细胞移植
Abstract： 目的 观察供者表达活化性杀伤细胞免疫球蛋白样受体(aKIR)对受者造血干细胞移植(HSCT)预后的影响.方法 1996年至2001年共行亲缘性人类白细胞抗原(HLA)全相合骨髓移植59例,以序列特异性引物多聚酶链反应法(SSP-PCR)检测供者aKIR的表型.分析供者表达aKIR对受者移植后病毒、细菌和真菌感染及出血、复发、存活情况的影响.结果 供者表达aKIR与受者移植后出血、病毒及细菌感染发生的概率无明显相关性;当供者表达KIR3DS1表型时,发生真菌感染概率增高(χ2=4.804,P=0.028).供者表达aKIR对受者HSCT后存活率和白血病复发率均无明显影响.结论 亲缘性HLA全相合HSCT中,供者表达aKIR并不能改善受者的移植效果.
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