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Repair and reconstruction mechanism of stromal cell derived factor-1 on rat abdominal aorta grafts

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
Issue:
6
DOI:
10.3760/cma.j.issn.0254-1785.2006.06.001
Key Word:
基质衍生因子-1;主动脉,腹;免疫组织化学

Abstract: 目的探讨基质衍生因子-1(SDF-1)在大鼠腹主动脉移植术后介导的修复重构机制.方法雄性Wistar大鼠为供者,雄性SD大鼠为受者,建立腹主动脉原位移植模型.免疫组织化学技术检测受者移植动脉内皮细胞上SDF-1的表达以及血管内膜的厚度;逆转录-聚合酶链法(RT-PCR)检测移植动脉血管中SDF-1受体CXCR4的表达.结果受者移植的腹主动脉内皮细胞上持续表达SDF-1,且其表达水平与术后血管内膜增生厚度密切相关.结论SDF-1能动员干细胞至移植的腹主动脉,并分化成平滑肌样细胞.SDF-1可能成为预警血管硬化、慢性移植物功能丧失发生和发展的指标.

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