You Position: Home > Paper
Combined extended radical resections and orthotopic liver transplantation for the treatment of hilar cholangiocarcinoma: one case report
( views:286, downloads:32 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.0254-1785.2006.04.004
- Key Word:
- 肝移植;胰十二指肠切除术
Abstract： 目的评价原位肝移植联合胰头及十二指肠根治性整块切除(Whipple法)治疗Ⅳ型肝外胆管癌的可行性.方法对1例Ⅳ型(Bismuth-Corlette分型)肝外胆管癌侵犯肝内二级胆管及胆总管胰腺段的患者,实施原位肝移植联合胰头及十二指肠根治性切除手术(HPLTx).术后应用他克莫司(FK506)+甲泼尼龙二联免疫抑制方案;给予拉米夫定+大剂量乙型肝炎免疫球蛋白静脉滴注抗病毒治疗.采用免疫组织化学法检测病肝中肝细胞蛋白、癌胚抗原、胆管上皮细胞角蛋白(CK9、CK17)的表达.结果病肝标本病理诊断为浸润型低分化胆管癌.患者移植肝功能恢复顺利,血清甲胎蛋白、癌胚抗原、肿瘤相关抗原(CA19-9、CA125)均降至正常范围,未见肿瘤复发.结论实施HPLTx可提高肝门部Ⅳ型胆管癌手术R0切除率,可获得较好的预后.
- [1]赵建勋,乔岐禄,孙占祺,等.肝门胆管癌手术切缘残癌与预后[J].2001,(2).
- [2]黄志强.肝胆外科--从20世纪到21世纪[J].2005,(1).
- [3]H, Bismuth,R, Nakache,T, Diamond.Management strategies in resection for hilar cholangiocarcinoma.[J].1992,215.
- [4]Jonas, S.,Kling, N.,Guckelberger, O.,etc.Orthotopic liver transplantation after extended bile duct resection as treatment of hilar cholangiocarcinoma[J].1998,11(1).
- [5]T E, Starzl,S, Todo,A, Tzakis,etc.Abdominal organ cluster transplantation for the treatment of upper abdominal malignancies.[J].1989,210.
- [6]P, Neuhaus,S, Jonas,W O, Bechstein,etc.Extended resections for hilar cholangiocarcinoma.[J].1999,230.