You Position: Home > Paper
A new therapy to intractable rejection after liver transplantation
( views:251, downloads:28 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.0254-1785.2006.04.001
- Key Word:
- 肝移植;移植物排斥;免疫抑制剂
Abstract： 目的探讨一种治疗肝移植术后顽固性排斥反应的新方法.方法经病理证实的肝移植术后急性排斥反应2例、慢性排斥反应2例,这4例患者在应用常规治疗方法无效的情况下,应用低剂量他克莫司(FK506)+西罗莫司(SRL)进行治疗,FK506和SRL的血药浓度分别控制在3～5μg/L和6～12μg/L.排斥反应纠正后停用SRL,并将FK506调整至常规用量.结果4例患者的排斥反应均得以纠正,在应用本方案的过程中出现巨细胞病毒性肺炎1例,经抗病毒治疗后痊愈;原有糖尿病加重1例,新发生糖尿病1例,停用SRL同时应用胰岛素控制血糖,治疗后血糖恢复正常水平.结论肝移植术后经常规治疗方法无效的急、慢性排斥反应,应用低剂量FK506+SRL进行治疗,排斥反应可以得到逆转.
- [1]Seguel JM,Merchant A,Koneru B,etc.Effect of sirolimus on infection incidence in liver transplant recipients.[J].2004,10(2).
- [2]Appelbaum FR,Anasetti C,Witherspoon R,etc.Sirolimus (rapamycin) for the treatment of steroid-refractory acute graft-versus-host disease.[J].2001,72(12).
- [3]Bejarano PA,Weppler D,Montalbano M,etc.A retrospective review of sirolimus (Rapamune) therapy in orthotopic liver transplant recipients diagnosed with chronic rejection.[J].2003,9(5).
- [4]Muthukkumar S,Bondada S,Ramesh TM.Rapamycin, a potent immunosuppressive drug, causes programmed cell death in B lymphoma cells.[J].1995,60(3).