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The effect of nonfunctioning allograft nephrectomy on the level of anti-HLA antibody in sensitive recipients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.0254-1785.2006.01.001
- Key Word:
- 肾移植;肾切除术;抗体生成
Abstract： 目的探讨无功能移植肾切除对致敏受者的抗HLA抗体的影响.方法采用Lambda公司生产的抗原板(LAT)、微量酶联免疫吸附法,测定51例致敏患者无功能移植肾切除前后外周血中特异性抗HLA Ⅰ类和Ⅱ类抗体水平,分析其变化的临床意义.结果移植肾切除前单纯抗Ⅰ类抗体升高者15例(29.4%),其抗HLA Ⅰ类抗体水平在术后12个月时由切除前的(49.97±27.07)%下降至(31.01±27.87)%,差异有统计学意义,且轻度升高者的下降程度明显大于中度以上升高者(P＜0.05);移植肾切除前单纯抗Ⅱ类抗体升高者12例(23.5%),术后3个月时抗HLA Ⅰ类和Ⅱ类抗体分别由(4.18±1.36)%和(58.34±21. 04)%升高至(13.38±13.11)%和(79.56±18.96)%,差异有统计学意义,没有一例患者的抗HLAⅡ类抗体能降至正常水平;移植肾切除前抗Ⅰ类和Ⅱ类抗体均升高者24例(47.1%),术后6个月时两类抗体的水平较术前明显下降,此后抗HLA Ⅰ类抗体水平升高,而抗HLAⅡ类抗体则继续下降,但多数患者的两类抗体水平仍＞30%.结论单项抗HLA Ⅰ类抗体升高,且抗体水平≤30%的致敏受者适合切除功能丧失的移植肾.
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