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Auxiliary partial orthotopic liver transplantation for acute hepatic failure: establishment of a new model
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 12
- DOI:
- 10.3760/cma.j.issn.0254-1785.2005.12.001
- Key Word:
- 肝功能衰竭,急性;猪;肝移植
Abstract： 目的建立猪原位辅助性肝移植(APOLT)治疗急性肝功能衰竭的动物模型,并评价其治疗效果.方法选取健康雌性良种幼猪18头,其中12头建立急性肝功能衰竭模型,另6头作为肝移植的供者.将急性肝功能衰竭的幼猪随机平均分为2组:对照组,不作任何处理;实验组,进行APOLT术,切除受者肝脏左叶,将修整后的供肝右叶移植于原肝左叶肝床处,供肝肝上下腔静脉与受者肝肝上下腔静脉行端侧吻合,供肝门静脉与受者肝门静脉行端侧吻合,受者脾动脉在结肠后与供肝动脉行端端吻合,胆总管置管外引流.结果对照组7 d生存率仅为17%,而实验组为83%.实验组术后第7 d肝功能基本恢复正常,组织学检查示原肝细胞再生明显.结论门静脉注射氨基半乳糖+脂多糖诱导的猪急性肝功能衰竭是一个理想的动物模型;APOLT对急性肝功能衰竭具有较好的疗效.
- [1]彭承宏,史留斌,彭淑牖,等.新辅助性原位部分肝移植动物模型的建立[J].2002,(15).
- [2]SR Bramhall,E Minford,B Gunson,etc.Liver transplantation in the UK[J].2001,(5).
- [3]H, Bismuth,D, Azoulay,D, Samuel,etc.Auxiliary partial orthotopic liver transplantation for fulminant hepatitis. The Paul Brousse experience.[J].1996,224.
- [4]Fukao K,Taniguchi H,Yuzawa K,etc.Establishment of a swine model for auxiliary partial orthotopic liver transplantation.[J].1998,30(7).
- [5]Asonuma K,Tanaka K,Kiuchi T,etc.Auxiliary partial orthotopic liver transplantation from living donors: significance of portal blood flow.[J].1998,66(4).
- [6]Kasahara M,Takakura K,Uemoto S,etc.Auxiliary partial orthotopic liver transplantation as a rescue for small-for-size grafts harvested from living donors.[J].1998,30(1).