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Impacts of recipient's SNP of cytokine and cytokine receptor on the incidence of infection after renal transplantation
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.0254-1785.2005.09.005
- Key Word:
- 肾移植;细胞活素类;受体,细胞活素;多态现象;感染
Abstract： 目的探讨肾移植受者的某些细胞因子及其受体基因多态性与术后感染的相关性.方法采用自行研制的细胞因子及其受体单核苷酸多态性检测芯片,分析129例肾移植受者的肿瘤坏死因子(TNF-α)、白细胞介素10(IL-10)、转化生长因子(TGF-β1)、IL-4、IL-6及其受体的21个位点的基因多态性分布情况,并按照患者术后是否发生感染进行分组比较.结果5种细胞因子及其受体单核苷酸多态性在感染组和非感染组中分布明显不同,分别是基因型IL-6R(-183GG、G/A)、IL-10(-824C/T,-597 C/A)及TNF-α(-308GG、G/A);等位基因为IL-10R1(1112G/A)、IL-6R(-183G/A)、IL-4R(1902A/G)、TNF-α(-308G/A)及TGF-β1(+869T/C).结论基因型IL-6R(-183GG)、IL-10(-824C/T,-597 C/A)及TNF-α(-308GG),等位基因IL-4R(1902A)、IL-6R(-183G)、IL-10R1(1112G)、TNF-α(-308G)及TGF-β1(+869C)是肾移植后感染的易患因素;而基因型IL-6R(-183G/A)和TNF-α(-308G/A)可能为移植后感染的非易患因素.
- [1]舒强,方向明,陈齐兴,等.IL-10 polymorphism is associated with increased incidence of severe sepsis[J].2003,(11).
- [2]El-Gamel A,Turner DM,Awad MR,etc.Genotypic variation in the transforming growth factor-beta1 gene: association with transforming growth factor-beta1 production, fibrotic lung disease, and graft fibrosis after lung transplantation.[J].1998,66(8).
- [3]D, Turner,S C, Grant,N, Yonan,etc.Cytokine gene polymorphism and heart transplant rejection.[J].1997,64.
- [4]Keiko Tanaka,Mark H. Roberts,Naoko Yamamoto,etc.Genetic Variants of the Receptors for Thromboxane A2 and IL-4 in Atopic Dermatitis[J].2002,292(3).
- [5]San-Millan JoseL,Sancho Jose,Villuendas Gemma,etc.The -597 G-->A and -174 G-->C polymorphisms in the promoter of the IL-6 gene are associated with hyperandrogenism.[J].2002,87(3).
- [6]Zimmermann N,Rosa Rosa-L,Rothenberg ME,etc.The R576 IL-4 receptor alpha allele correlates with asthma severity.[J].1999,104(5).
- [7]G K, Hershey,M F, Friedrich,L A, Esswein,etc.The association of atopy with a gain-of-function mutation in the alpha subunit of the interleukin-4 receptor.[J].1997,337.
- [8]Scarel Caminaga RM,Souza AP,Trevilatto PC,etc.Frequencies of the -330 (T --> G) IL-2 and -590 (T --> C) IL-4 gene polymorphisms in a population from south-eastern Brazil.[J].2002,29(4).
- [9]Reinisch W,Williams LM,Sarma U,etc.Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-alpha production.[J].2003,170(11).
- [10]H. Asano,T. Kobayashi,K. Uchida,etc.Significance of tumor necrosis factor microsatellite polymorphism in renal transplantation[J].1997,50(5).
- [11]Saloman R,Supran S,Kang S,etc.Tumor necrosis factor genetic polymorphisms correlate with infections after renal transplantation.[J].2000,69(5).
- [12]Keijsers V,Eskdale J,Gallagher G,etc.Interleukin 10 secretion in relation to human IL-10 locus haplotypes.[J].1998,95(16).
- [13]Cambien F.,Ricard S.,Troesch A.,etc.Polymorphisms of the Transforming Growth Factor-\u00a01 Gene in Relation to Myocardial Infarction and Blood Pressure: The Etude Cas-Temoin de l'Infarctus du Myocarde (ECTIM) Study[J].1996.
- [14]MICHEL GOLDMAN,ARNAUD MARCHANT,LILIANE SCHANDENÉ.Endogenous Interleukin-10 in Inflammatory Disorders: Regulatory Roles and Pharmacological Modulation[J].1996,796(1).
- [15]Aihara R,Tran CL,Supran S,etc.Tumor necrosis factor genetic polymorphisms correlate with infections after liver transplantation. NEMC TNF Study Group. New England Medical Center Tumor Necrosis Factor.[J].1999,67(7).
- [16]Carson D,Rance H,Maier LM,etc.Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene.[J].2003,4(7).
- [17]Kluter H,Fricke L,Bein G,etc.The IL-4 receptor alpha-chain variant Q576R is strongly associated with decreased kidney allograft survival.[J].1999,54(5).
- [18]Reid Felecia,Kimball Pam.Tumor necrosis factor beta gene polymorphisms associated with urinary tract infections after renal transplantation.[J].2002,73(7).