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Prolongation of rat heart allograft survival by Toxoplasma Gondii
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 9
- DOI:
- 10.3760/cma.j.issn.0254-1785.2005.09.003
- Key Word:
- 心脏移植;弓形虫属;感染;移植物存活;大鼠
Abstract： 目的探讨受者弓形虫感染对同种心脏移植物存活时间的影响.方法通过腹腔注射的方法建立弓形虫感染的大鼠模型,分别于感染后4～7 d(急性感染组)或感染后27～32 d(慢性感染组)进行同种异体颈部心脏移植,并设注射生理盐水的对照组和同系移植对照组.术后不用免疫抑制剂,观察移植心脏的存活时间以及移植物的病理变化.结果同系对照组的移植物存活时间为(135.3±30.4)d;慢性感染组移植心脏的存活时间为(73.6±49.3)d,明显长于生理盐水对照组和急性感染组(P＜0.01),其移植心脏组织中的炎症细胞浸润也较对照组显著减轻,尤其是移植物存活时间超过100 d者,无慢性移植物病变.结论受者的弓形虫感染能显著延长同种心脏移植物的存活时间,减轻移植物炎症反应.
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