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Prevention and treatment of cyomegalovirus reinfection after liver transplantation
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.0254-1785.2005.03.003
- Key Word:
- 肝移植;巨细胞病毒感染;临床方案
Abstract： 目的探讨肝移植术后巨细胞病毒(CMV)再感染的预防、诊断及治疗.方法回顾性分析44例原位肝移植患者的临床资料.结果44例中,术前43例(97.7%)有CMV潜伏性感染,其中6例(14.0%)术后发生CMV再感染.6例CMV再感染患者的CMV pp65抗原均为阳性,3例CMV IgM阳性,均为无临床症状的CMV活动性感染,其中5例治愈,无一例发展为CMV病,1例因上消化道大出血死亡.43例中,仅有7例CMV再感染高危病例接受了抗CMV感染的预防性治疗,患者在生存期内未发生CMV再感染.结论在我国,肝移植患者术前CMV潜伏性感染的发生率较高,测定CMV pp65抗原可以早期诊断CMV再感染;对CMV再感染的高危患者进行预防性治疗可以降低术后CMV再感染的发生率;对无临床症状的CMV再感染者进行及时、规范的治疗是防止CMV病发生的关键.
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