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Effects of AG490 on proliferation of human lymphocyte
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.0254-1785.2005.02.002
- Key Word:
- 蛋白质酪氨酸激酶;淋巴细胞;免疫抑制剂
Abstract： 目的探讨AG490作为免疫抑制剂的的可能性及其基本作用机制.方法分别应用植物血凝素(PHA)和白细胞介素2(IL-2)与淋巴细胞混合培养(MLC),诱导人淋巴细胞产生增殖;观察在不同的干预剂AG490、环孢素A(CsA)及他克莫司(FK506)作用下,人淋巴细胞增殖的抑制率、细胞因子(IL-2、IL-6、IFN-γ)的分泌及淋巴细胞亚群分化的变化.结果AG490在体外实验中,对于多种条件引起的人淋巴细胞(T、B淋巴细胞混合存在)增殖反应均有明显的抑制作用.尤其是对于CD3+细胞及CD4+细胞,其抑制作用更为明显.可以显著抑制多种条件引起的IL-2、IFN-γ的分泌,但对于IL-6分泌无抑制作用.结论AG490是一种潜在的免疫抑制剂,具有较大的研究和应用前景.
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