You Position: Home > Paper
Renal allograft long-term function protection with enalapril
( views:207, downloads:0 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.0254-1785.2005.01.005
- Key Word:
- 肾移植;依那普利;转化生长因子β;细胞保护
Abstract： 目的探讨血管紧张素转换酶抑制剂依那普利对移植肾远期功能的保护作用.方法对肾移植术后存活超过1年、移植肾功能正常、尿转化生长因子β1(TGF-β1)相对浓度≥250.0pg/mgCr者连续使用依那普利1年以上,并设立相同条件下不用依那普利的对照组,3年后比较两组发生肾功能异常的例数、肌酐清除率(Ccr)的减少量、血及尿中TGF-β1的浓度;观察服用依那普利前后移植肾组织中TGF-β1mRNA表达量的变化以及服用依那普利的不良反应.结果 3年后,使用依那普利者发生肾功能异常的例数明显低于对照组(P＜0.05),Ccr减少量及尿TGF-β1相对浓度也明显低于对照组(P＜0.01,P＜0.01),但两个组血TGF-β1浓度的差异无统计学意义;服用依那普利1年后,移植肾组织中TGF-β1mRNA表达量显著降低(P＜0.01);发生肾功能异常者,移植肾组织呈现慢性移植肾肾病表现;未观察到与依那普利相关的不良反应.结论依那普利对移植肾的远期功能具有保护作用,其作用机理可能与依那普利抑制TGF-βt分泌有关.
- [1]张国华,张训,侯凡凡,等.转化生长因子β1在实验性慢性环孢素A肾病中的作用[J].2000,(4).
- [2]杨志豪,张钊,姜永金.血管紧张素转换酶抑制剂治疗肾移植后继发性红细胞增多症[J].2001,(1).
- [3]Ritz E,Rump LC,Orth SR,etc.Glomerulosclerosis and progression: effect of subantihypertensive doses of alpha and beta blockers.[J].2001,60(4).
- [4]Clesca PH,Lario S,Campistol JM,etc.Losartan decreases plasma levels of TGF-beta1 in transplant patients with chronic allograft nephropathy.[J].1999,56(2).
- [5]Young Kim W,Woo Yang C,Young Jung J,etc.Synergistic effects of mycophenolate mofetil and losartan in a model of chronic cyclosporine nephropathy.[J].2003,75(3).
- [6]Wahab NA,Weston BS,Mason RM,etc.Connective tissue growth factor and regulation of the mesangial cell cycle: role in cellular hypertrophy.[J].2002,13(10).
- [7]Paul LC.Chronic allograft nephropathy: An update.[J].1999,56(3).
- [8]Silvestri P,Nanni G,Citterio F,etc.Plasma levels of transforming growth factor-beta1 in renal transplant recipients receiving different immunosuppressive regimens.[J].2004,36(3).
- [9]Rodicio JL,Morales JM,Andres A,etc.Influence of cyclosporin, tacrolimus and rapamycin on renal function and arterial hypertension after renal transplantation.[J].2001,16(Suppl.1).