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Effects of liposomal prostaglandin E1 on hepatic allograft vascular inflow
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.0254-1785.2004.01.003
- Key Word:
- 肝移植;前列地尔;移植物;血流速度
Abstract： 目的评价前列地尔的脂微球载体制剂对肝移植术后早期肝动脉、门静脉血流的影响.方法 56例肝移植受者在术后被随机分成两组:前列地尔治疗组和对照组,治疗组从手术当天起至术后14 d每天静脉注射前列地尔20μg.两个组均接受环孢素A(或他克莫司)联合泼尼松预防排斥反应,术后第1、3、5、7、9、14 d以彩色多普勒超声测定两组肝门部肝动脉的峰值速度(HAV)、门静脉主干的血流速度(PVV)及门静脉主干血流量(PVFV).结果两组受者术后2周内的HAV均逐渐增高,而PVFV呈下降趋势;术后1～5 d时治疗组的HAV显著高于对照组(P＜0.05);两组间PVFV的差异无显著性.结论前列地尔脂微球载体制剂对肝移植术后早期肝动脉的血流有明显的促进作用,但对早期门静脉的血流影响不大.
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