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Expressions of apoptosis associated factors and adhesion molecules in acute rejection of rat cardiac allografts
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.0254-1785.2003.06.107
- Key Word:
- 心脏移植;凋亡;Fas/FasL;Bcl-2/Bax;粘附分子
Abstract： 目的探讨凋亡及凋亡相关因子Fas/FasL、Bcl-2/Bax,粘附分子ICAM-1、P-selectin、E-selectin、L-Selectin、PECAM-1和VCAM-1在心脏移植中的表达及意义.方法用免疫组织化学方法和原位杂交法,检测大鼠心脏移植后不同时间(1、3、5、7d)、Fas/FasL、ICAM-1、P-selectin、L-selectin、E-selectin蛋白、Bcl-2/Bax、VCAM-1、PECAM-1 mRNA的表达情况.结果随着移植后天数的增加,细胞凋亡增多,Fas/FasL、Bax表达增加,粘附分子ICAM-1、 VCAM-1、 PECAM-1表达也增加,Selectin表达较少.正常大鼠肝脏未见细胞凋亡及粘附分子的表达.结论细胞凋亡和粘附分子ICAM-1、VCAM-1、PECAM-1表达增加可能与心脏移植后急性排斥反应有关,而Fas/FasL、Bax可能促进了凋亡的发生.
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