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Inhibit of acute rejection by TⅡin rat liver xenotransplantation
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.0254-1785.2003.06.101
- Key Word:
- 移植,异种;移植物排斥;雷公藤多甙
Abstract： 目的研究雷公藤多甙(TⅡ)对大鼠异种肝移植急性排斥的抑制作用.方法以雌性仓鼠为肝脏供者,雄性近交系Wistar大鼠为受者,循改进的Kamada法行原位肝移植术.供、受者各30只随机配对,平均分为2组:对照组和TⅡ治疗组(30mg*kg-1*d-1).观察两组受者生存期;分别取两组术后2h、72h及排斥死亡时受者的肝脏标本,行HE染色检查.结果对照组平均生存期为(7.1±0.35)d,TⅡ组(7.2±0.52)d,两组比较,差异无显著性;对照组及TⅡ组结膜充血的发生率分别为100%、31%, 两组差异有显著性(P=0.001);术后肝脏标本HE染色检测:(1)术后2h对照组和TⅡ组均未见排斥反应发生;(2)术后72h对照组出现排斥反应,且明显,而TⅡ组表现相对较轻;(3)受者7d左右死亡时,对照组排斥反应剧烈,TⅡ组排斥反应也很强烈,但不如对照组严重.结论单独应用TⅡ30mg*kg-1*d-1可轻度抑制大鼠异种肝移植急性排斥反应,但并不能延长受者的生存期;术后结膜充血可作为该模型急性排斥反应的一种表现,TⅡ可缓解这种体征.
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