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Nonmyeloablative allogeneic peripheral blood stem cell transplantation for chronic leukemia: a report of seven cases
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.0254-1785.2003.05.101
- Key Word:
- 造血干细胞移植;移植,同种;移植预处理
Abstract： 目的总结非清髓性异基因外周血造血干细胞移植(NASCT)治疗白血病的经验.方法对7例白血病患者进行非清髓性预处理,预处理采用抗CD3单克隆抗体、环孢素A、环磷酰胺及阿糖胞苷,4例患者加用氟达拉滨,随后施行HLA配型完全相合同胞供者的NASCT.术后采用环孢素A及甲氨蝶呤或环孢素A及霉酚酸酯预防移植物抗宿主病(GVHD).结果全部患者的造血功能均获得快速重建,中性粒细胞于术后9～12 d恢复到 0.5×109/L以上,血小板于术后11～28 d恢复到 30.0×109/以上.7例中,4例完全植入,3例嵌合性植入.2例发生急性GVHD,其中1例死亡.结论 NASCT治疗慢性白血病疗效肯定,并发症少,是治疗白血病的有效方法.
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