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Clinical use of cross reactive groups matching in highly sensitized recipients of kidney recipients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.0254-1785.2003.03.106
- Key Word:
- 免疫法;肾移植;组织相容性试验;抗体特异性
Abstract： 目的探讨交叉反应组(CREG)配型在高致敏患者肾移植中的临床意义.方法动态监测肾移植受者体内群体反应性抗体(PRA)的水平及其特异性,按照CREG配型原则选择最匹配的供者.结果60例受者术前PRA超过11%,均有单纯性或混合性升高;按照CREG配型,0～1个抗原错配、2个抗原错配、3～4个抗原错配者术后肌酐恢复正常的时间平均为6.5 d、7.0 d、12.7 d,发生肾功能恢复延迟的例数分别为0、7例、3例,各组间的差异具有显著性(P＜0.05).结论高致敏受者在肾移植时采用CREG配型,可避开受者预存的HLA抗体特异性所对应的抗原,对于提高肾移植人/肾存活率具有重要意义.
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