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Pretreatment with FTY720 alone induced tolerance to mouse heart allograft
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.0254-1785.2002.05.101
- Key Word:
- 免疫抑制剂;小鼠,近交系;心脏移植;免疫耐受;脱噬作用
Abstract： 目的观察术前使用FTY720对小鼠同种异体心脏移植物存活时间的影响.方法以小鼠颈部异位心脏移植为模型,供者为BALB/c小鼠,受者为C57BL/6小鼠.受鼠分为4组:A组为空白对照组;B组术前3d至术后11d每日管饲FTY720;C组手术当天至术后14d每日管饲FTY720;D组仅在术前3 d至手术当天每日管饲FTY720.FTY720的剂量都为3mg*kg-1*d-1.结果 A组移植物中位存活时间(MST)为8d;B组所有移植物存活时间均超过27d,有半数(6/11)移植物存活超过100d;C组移植物存活时间显著延长(MST=16d);D组移植物中位存活时间为14d,并有1只超过100d.结论术前使用FTY720可以延长同种异体心脏移植物的存活时间,诱导受者对同种异体心脏移植物的耐受.
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