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Effect of high dose immunoglobulin on the panel reactive antibody
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.0254-1785.2002.03.104
- Key Word:
- 超敏反应;免疫球蛋白类;免疫法,被动;肾移植
Abstract： 目的研究大剂量免疫球蛋白对群体反应性抗体(PRA)的作用.方法取15例PRA值较高的等待肾移植的患者血清,加入大剂量免疫球蛋白,进行体外抑制实验;其中5例患者静脉注射大剂量免疫球蛋白,进行了体内抑制实验,4例患者用药1个疗程(每周0.5 g/kg,共4周),另一例用药2个疗程,2例PRA降至10%左右的患者分别接受了肾移植和胰、肾联合移植.结果体外实验显示,患者血清中加入大剂量免疫球蛋白的淋巴细胞死亡率和淋巴细胞毒实验的阳性率均较对照组低;接受静脉注射大剂量免疫球蛋白的患者,PRA下降2%～51%,平均降幅为23%;接受肾移植的患者,术后给予常规免疫抑制治疗方案,曾发生急性排斥反应,经冲击逆转,肾功能正常;接受胰、肾联合移植的患者,术后未发生排斥反应,移植胰、肾功能正常.结论静脉注射大剂量免疫球蛋白可降低部分高敏患者的PRA值,其作用与用药量大小成正比.
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