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Synergistic effects of tacrolimus with FK778 or FK779 in prevention of acute heart allograft rejection in the rat
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.0254-1785.2002.01.105
- Key Word:
- 大鼠;心脏移植;免疫抑制剂
Abstract： 目的评价他克莫司(FK506)与FK778 或FK779联合应用预防大鼠心脏移植排斥反应的效果. 方法大鼠异位心脏移植后单独应用FK506、FK778和FK779进行免疫抑制治疗,并设联合用药组. 结果单独用药组与不用药对照组相比,移植心脏存活时间明显延长,FK779组尤其显著;联合用药组移植心脏存活时间不但比对照组明显延长,而且明显长于各药同剂量单用组,FK506与FK779合用组尤其显著. 结论 FK506、FK778和FK779均有很强的免疫抑制效应,FK506与FK7 78或FK779联合应用具有较强的协同效应.
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