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Tolerance induction to cardiac allografts produced by neonatal intrathymic or intraperitoneal injection of donor spleen cells
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.0254-1785.2001.05.105
- Key Word:
- 动物,新生;免疫耐受;心脏移植;大鼠
Abstract： 目的探讨诱导新生大鼠免疫耐受的方法.方法分别给新生SD大鼠胸腺或腹腔内注射2.5×107个Wistar大鼠脾淋巴细胞,8～10周龄时行Wistar及第三品系大鼠供心移植.结果胸腺或腹腔注射Wistar大鼠脾淋巴细胞者移植Wistar大鼠心脏后移植物的存活时间显著延长,胸腺注射者平均存活时间超过60.4*!d(P＜0.001),腹腔注射者平均存活时间为15.8*!d(P＜0.02),而第三品系大鼠的心脏移植后平均存活9.2*!d(P＞0.05).结论单一胸腺或腹腔内注射同种脾细胞可以诱导新生大鼠的特异性免疫耐受.
- [1]范太兵,丁文祥,黄惠民,等.胸腺内接种同种脾细胞诱导新生期大鼠免疫耐受的研究[J].1999,(2).
- [2]K, Seo,Y, Imai,S, Imamura,etc.Induction of neonatal immunologic tolerance to heart transplantation by intrathymic myocardial cell inoculation in rats.[J].1900,12(6 Pt 2).