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Clinical study on increased blood concentration of cyclosporin A by berberine hydrochloride in renal transplanted recipients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.0254-1785.2001.04.107
- Key Word:
- 肾移植;环孢菌素;药物监测
Abstract： 目的研究盐酸小檗碱(Ber)对肾移植受者环孢素A(CsA)血浓度的影响.方法 33例肾移植后口服CsA+Ber的受者为试验组,27例单纯口服CsA的受者为对照组,以CsA全血浓度及肝、肾功能生化检测指标作为临床评价指标.结果试验组受者CsA全血浓度与合用Ber前比较,增幅达66.9%,与对照组比较差异有显著性(P<0.001),停用Ber后,CsA全血浓度显著下降.Ber与CsA合用对肝、肾功能无明显影响.结论 Ber能显著升高肾移植受者CsA血浓度.在升高CsA血浓度的同时,Ber并不增加CsA的毒性反应.Ber与CsA合用有望成为一种节省CsA费用的方法.
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