Abstract： Objective To summarize the experience of one case of single lung transplantation undergoing cardiac puhnonary.Methods One case of end-stage pulmonary fibrosis underwent left single lung transplantation.The donor lung was lavaged with Euro-Collins mlution.The duration of esophagus anastomosis lasted 55 min.After operation,cyclosporine A,hormones and azathiopurine were used for immunosuppressive therapy.Results The grafted lung immediated functioned after operation.Heart clogging occurred due to bleeding 1,2 d after operation.Hemostasis was performed two times.Acute rejection reaction occurred on day 3 and 7.The patients died of acute rejection reaction on the day 9.Conclusions The monitoring and controlling of bleeding and acute rejection after lung transplantation should be strengthened.