Abstract： Objective To explore the protective and monitoring methods for the donor heart coronary proliferative disease of the long-term survivals of heart transplantation.Methods Five long-term survivors of heart transplantation were studied.Each patient administered angiotensin converting enzyme inhibitors,nitrates and pravastatin after the cardiac transplantation.The relationship between ECG ST-T changes,clinical symptoms(such as chest pain,etc.),hypertension,hyperglycemia,hyperlipemia and coronary angiography were studied.Results Five cardiac transplants received corollary angiography 6,4,3.1 and 1 years after heart transplantation.No coronary stencxsis was found.Conclusions Hypertension,hyperglycemia and hyperlipemia might not be the"risk factors"for the donor heart coronary proliferative disease.The chest pain and ECG ST-T changes didn't suggest the insufficiency of coronary blood supply.Periodical coronary angiography had a significantly clinical value.