Expressions of CD69,CD25 and CD71 on CD3+ lymphocytes in peripheral blood in the patients with kidney transplantation and its implication
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF ORGAN TRANSPLANTATION
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.0254-1785.2000.04.104
- Key Word:
- 肾移植;CD3;CD69;CD25;CD71;Kidney transplantation;CD3;CD69;CD25;CD71
Abstract： Objectives To investigate the expression of CD69,CD25 and CD71 on CD3+ cells inperipheral blood in patients undergoing kidney transplantation and implication.Methods The lymphocytes from the peripheral blood in patients after renal transplantatiort in different periods were immunologically lamined by flow cytometry(FCM). Results The levels of CD3/CD69,CD3/CD25 and CD3/CD71 were lower in the groups of stable allograft condition and CsA nephrotoxicity (P＜0.05)and markedly higher in the groups of acute reieqtion and infection(P＜0.01) than those in pre-transplantation group.The increasing in the groups of acute rejection and infection emerged 1 to 4 days prior to clinical diagnosis.Conclusions The dynamic assay of CD69,CD25 and CD71 on CD3+ lymphocytes is helpful to the early diagnosis and differential diagnosis of acutekidney rejection,and is of some importance for the treatment of rejection and the evaluation of the curative effects of antirejection.
- [1]Efstathios Alexopoulos,Maria Leontsini,Michael Daniilidis,etc.Differentiation Between Renal Allograft Rejection and Cyclosporine Toxicity: A Clinicopathological Study[J].1991,18(1).
- [2]P, Brekelmans,P, van Soest,P J, Leenen,etc.Inhibition of proliferation and differentiation during early T cell development by anti-transferrin receptor antibody.[J].1994,24(11).
- [3]R, Dittmer,P, Harfmann,W, Tenschert,etc.Monitoring of renal transplant patients with interleukin-2 and interleukin-2 receptor enzyme immunoassay and interleukin-2 receptor immunocytology.[J].1990,22.
- [4]Erren M,Schmidt C,Roeder N,etc.T-cell and monocyte subsets, inflammatory molecules, rejection, and hemodynamics early after cardiac transplantation.[J].1998,65(9).
- [5]T.G Paglieroni,R Perez,S Katznelson,etc.Donor cell induced CD69 expression and intracellular IL-2 and IL-4 production by peripheral blood lymphocytes isolated from kidney transplant recipients[J].1999,60(1).
- [6]A I, Beik,A G, Morris,R M, Higgins,etc.Serial flow cytometric analysis of T-cell surface markers can be useful in differential diagnosis of renal allograft dysfunction.[J].1998,12(1).