Abstract： Objective To increase the survival rate of end-stage liver diseases. Methods The piggyback orthotopic liver transplantation was successfully performed in 4 cases from May 1996 to Feb. 1998 in our hospital. Among the 4 cases, one received operation of reduced-size piggyback orthotopic liver transplantation. Results Except one case of the cirrhosis caused by the hepatitis B died from the recurrence of hepatitis B with acute hepatic necrosis and acute pancreatitis, 3 cases of Wilson disease recovered smoothly with satisfactory results post transplantation. They have healthily survived 575 days, 390 days and 162 days, respectively. Conclusion Liver/transplantation is the best effective treatment for the most end-stage liver diseases at present.