Abstract： Objective To investigate the survival of fetal rat cerebral cortex homografted to adult rat brain and neural connection between recipients brain and grafting tissue.Methods Normal male adult Wistar rats were used as host or recipients,and the donor tissues were obtained from 15 to 17th day fetus of Wistar rats.The donor tissues were taken from the cerebral cortex of fetus and cut into pieces which were transplanted into the brain cavity previously prepared of the recipients.Transplanted rats received daily intraperitoneal iniection of 10 mg/kg cyclosporin A for 2 weeks to prevent immuno-rejection.All the animals were killed at different intervals(1 to 5 months)by perfusing fixative solution transcardially.The sections of rat brain specimens were stained with ABC immunohistochemistry and examined by light and electron microscope.Results Only 30% of the homografts survived and the sereotonergic-like nerve fibers were projected from host brain tissue.Conclusion The grafted tissue of fetal brain cortex might survive and form neural connections with the cerebral cortex of recipients after homograit transplantation.