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Modeling and comparing of HLA from donor and recipient in bone marrow Allotransplantation

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Author:
No author available
Journal Title:
CHINESE JOURNAL OF ORGAN TRANSPLANTATION
Issue:
3
DOI:
10.3760/cma.j.issn.0254-1785.1998.03.102
Key Word:
组织相容性抗原;组织相容性试验;分子构象;移植物抗宿主病;Key words Histocompatibility antigens Histocompatibility testing Molecular conformation Graft vs host disease

Abstract: Two pairs of HLA from donor and recipient of bone marrow allotransplantation with severe graft versus host disease (GVHD) were selected to perform structure modeling and comparison each other. The differences among these HLA proteins were found in surface conformation modeled by computer, Which were the main factors to prime GVHD after transplantation.It was suggested that the computerized modeling and comparing of HLA from donor and recipient might be used to prognose GVHD.

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