Abstract： The changes in levels of BMD, BGP, PTH, SCr, BUN, Ca2+, P3- were detected in 64 renal transplantation recipients to investigate their interactions and clinical implication.The results showed that serum SCr,BUN,PTH,BGP and P3- were in high level,and the levels of serum Ca2+ and BMD were obviously lower chan those of control group before renal transplantation.After renal trans.plantation,SCr,BUN,Ca,P,PTH and BGP returned to normal levels,and BMD to the level of control group 6 months postoperation.It was suggested that the patients with chronic renal failure within the period of hemodialysis existed obviously metabolic disorder of Ca 2+ and P3+,serious bony malnutrition.BMD might return to normal level after successful renal transplantation.