Abstract: From April 1992,othotopic heart transplantation (OHT) was successfully performed in 3 patients with late stage cardiomyopathy.The donor hearts were preserved by continuous retrograde reperfusion of tepid blood containing potassium during implantation.Among 3 cases,2 underwent standard OHT,one total OHT.Anastomoses were sutured in a continuous everting fashion.All patients were survived with good quality of life with survival time being 5 years,3 years and 1 year,respectively.It was suggested that continuous tepid reperfusion during implantation of donor heart is technically fcasiblc and sccms to provide enhanced myocardial preservation.Correct surgical procedures,carly diagnosis and effective treatment of acute rejection were the important factors for the improvement of early and late therapeutic effects after transplantation.