Abstract: This paper reports four cases of living related splenic transplantation for the treatment of hemophilia A,performed since 1989.Three cases were mother to son,and one father to son.The good results have been achieved in all four cases.After the transplants,the Ⅷ :C levels rose significantly for more than one year.The clinical phenomena of bleeding reduced markedly afterward.Up to now,three grafts still functionally survived,and the longest one was over four years.These are the best record in the world.