Evaluation of coronary heart disease risks in patients with psoriasis

( views:326, downloads:0 )
CHENG Yan(Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China)
CHEN Xiao-mei(Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China)
DUAN Xi(Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China)
ZHANG Min(Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China)
Journal Title:
Chinese Journal of Dermatology
Volume 45, Issue 09, 2012
Key Word:
Psoriasis; Coronary disease; Risk assessment

Abstract: Objective To estimate the 10-year risk of coronary heart disease in patients with psoriasis,and to determine whether the risk profile is affected by disease duration,family history and clinical types of psoriasis.Methods Data were pooled from 322 inpatients with psoriasis and 297 inpatients with other skin diseases (151 cases of acute urticaria,33 drug eruption,113 herpes zoster) from December 2008 to December 2010 in the Department of Dermatology,West China Hospital of Sichuan University.Risks of coronary heart disease were estimated by using the Framingham risk score algorithm.Wilcoxon rank test,Kruskal-Wallis test and chi-square tests were used to evaluate the differences in risks and risk factors between the patients with psoriasis and controls.Results As far as the Framingham 10-year risk score was concerned,the difference was statistically significant between the patients with psoriasis and the control population (6% vs.4%,Z =4.342,P =0.000),as well as between patients with different clinical types of psoriasis (6% for psoriasis vulgaris vs.4% for pustular psoriasis vs.7% for psoriasis arthropathica vs.7% for erythroderma psoriaticum,H =8.484,P < 0.05),but was insignificant between patients with familial and sporadic psoriasis (6% vs.6%,Z =0.406,P > 0.05 ).No correlation was observed between the Framingham 10-year risk and psoriasis duration (P > 0.05 ).Conclusions Increased risks of coronary heart disease exist in patients with psoriasis compared with those with acute urticaria,drug eruption or hepers zoster,and in patients with psoriasis arthropathica or erythroderma psoriaticum compared with those with pustular psoriasis.The Framingham 10-year risk of coronary heart disease is uncorrelated with disease duration and unaffected by family history of psoriasis.

  • [1]全国银屑病流行调查组.全国1984年银屑病流行调查报告.中华皮肤科杂志,1986,19(5):253-262.
  • [2]Schmitt J,Ford DE.Understanding the relationship between objective disease severity,psoriatic symptoms,illness-related stress,health-related quality of life and depressive symptoms in patients with psoriasis-a structural equations modeling approach.Gen Hosp Psychiatry,2007,29(2):134-140.
  • [3]Henseler T,Christophers E.Disease concomitance in psoriasis.J Am Acad Dermatol,1995,32(6):982-986.
  • [4]Cohen AD,Sherf M,Vidavsky L,et al.Association between psoriasis and the metabolic syndrome.A cross-sectional study.Dermatology,2008,216(2):152-155.
  • [5]Kimball AB,Guerin A,Latremouille-Viau D,et al.Coronary heart disease and stroke risk in patients with psoriasis:retrospective analysis.Am J Med,2010,123(4):350-357.
  • [6]Gisondi P,Farina S,Giordano MV,et al.Usefulness of the framingham risk score in patients with chronic psoriasis.Am J Cardiol,2010,106(12):1754-1757.
  • [7]Brauchli YB,Jick SS,Meier CR.Psoriasis and the risk of incident diabetes mellitus:a population-based study.Br J Dermatol,2008,159(6):1331-1337.
  • [8]Cohen AD,Dreiher J,Shapiro Y,et al.Psoriasis and diabetes:a population-based cross-sectional study.J Eur Acad Dermatol Venereol,2008,22(5):585-589.
  • [9]Gelfand JM,Neimann AL,Shin DB,et al.Risk of myocardial infarction in patients with psoriasis.JAMA,2006,296(14):1735-1741.
  • [10]Mehta NN,Yu Y,Pinnelas R,et al.Attributable risk estimate of severe psoriasis on major cardiovascular events.Am J Med,2011,124(8):775.e 1-e6.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn