Pathological characteristics of and human papillomavirus(HPV)genotype profile in subclinical HPV infection in patients with condyloma acuminatum

( views:104, downloads:0 )
Author:
HUANG Xi(Department of Dermatology, Affiliated Hospital of Guilin Medical College, Guilin 541000, Guangxi Zhuang Autonomous Region, China)
CHEN De-hua(Department of Dermatology, Affiliated Hospital of Guilin Medical College, Guilin 541000, Guangxi Zhuang Autonomous Region, China)
YANG Feng-yuan(Department of Dermatology, Affiliated Hospital of Guilin Medical College, Guilin 541000, Guangxi Zhuang Autonomous Region, China)
YAN Wen-jie(Department of Dermatology, Affiliated Hospital of Guilin Medical College, Guilin 541000, Guangxi Zhuang Autonomous Region, China)
Journal Title:
Chinese Journal of Dermatology
Issue:
Volume 44, Issue 10, 2011
DOI:
10.3760/cma.j.issn.0412-4030.2011.10.005
Key Word:
Condylomata acuminata;Vulva;Infection;Pathology

Abstract: Objective To investigate the clinicopathologic characteristics of and HPV subtypes in vulvar condyloma acuminatum(CA)and subclinical HPV infection.Methods Eighty patients with a positive acetowhite test and suspected subclinical HPV infection were selected from 272 patients with typical CA lesions in perianal and external genital region.Tissue specimens were obtained from typical CA and suspected subclinical HPV-infected lesions followed by pathological examination and HPV-DNA detection.Finally,71 patients were confirmed to suffer from both CA and subclinical HPV infection.A comparative analysis was performed to assess the differences in histopathological manifestation and HPV genotypes between CA and subclinical infection lesions.Results Pathological examination revealed typical histological changes of CA in 71(88.75%)typical CA specimens and 4(5%)suspected subclinical infection specimens,as well as squamous dysplasia in 9(11.25%)CA specimens and 71(88.75%)suspected subclinical infection specimens.HPV-DNA was positive in all(80)of the CA specimens and 93.75%(75)of the suspected subclinical infection specimens,negative in 5(6.25%)suspected subclinical infection specimens.Obvious differences were observed in pathological manifestation,koilocyte number(P < 0.05),but not in the distribution of HPV subtypes(P > 0.05),between typical CA and concurrent subclinical HPV infection lesions in patients.Conclusion The diagnosis of subclinical HPV infection should be based on the result of acetowhite test,with the results of pathological examination and HPV DNA detection as an adjuvant.

  • [1]Stanley M.HPV vaccines:are they the answer? Br Med Bull,2008,88(1):59-74.
  • [2]黄宗明,杨守京,李青,等.空泡细胞在诊断CA中的诊断价值.中华流行病学杂志,2001,22(1):58-60.
  • [3]Rieckmann P,Albrecht M,Ehrenreich H,et al.Semi-quantitative analysis of cytokine gene expression in blood and cerebrospinal fluid cells by reverse transcriptase polymerase chain reaction.Res Exp Med(Berl),1995,195(1):17-29.
  • [4]Herrero R,Castle PE,Schiffman M,et al.Epidemiologic profile of type-specific human papillomavirus infection and cervical neoplasia in Guanacaste,Costa Rica.J Infect Dis,2005,191(11):1796-1807.
  • [5]Jacquemier J,Penault F,Durst M,et al.Detection of five different human papillomavirus types in cervical lesions by in situ hybridization.A study of 110 cases using sulfonated probes.Hum Pathol,1990,21(9):911-917.
  • [6]刘荣,侯建玲,陈学超,等.醋酸白试验对CA患者HPV亚临床感染的评价.中华皮肤科杂志,2008,41(5):331-332.
  • [7]高宇,马新华,王荣跃.CA患者皮损中HPV的检测分型及HPV6b L1变异分析.中华皮肤科杂志,2010,43(5):336-338.
  • [8]Tu Y,Chen S,Fan C,et al.Telomerase activity in condyloma acuminatum tissue with different HPV types.J Huazhong Univ Sci Technolog Med Sci,2002,22(2):171-173.
  • [9]Clifford GM,Rana RK,Franceschi S,et aL Human papillomavirus genotype distribution in low-grade cervical lesions:comparison by geographic region and with cervical cancer.Cancer Epidemiol Biomarkers Prev,2005,14(5):1157-1164.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615 Email:yiyao@wanfangdata.com.cn