Association of polymorphisms of eIF4E and MMP-9 genes with psoriasis vulgaris in Han population of Shandong province

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Author:
CAI Da-xing(Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China)
SUN Qing(Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China)
MA Wei-yuan(Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China)
ZHONG Hua(Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China)
LI Chun-yang(Department of Dermatology, Qilu Hospital of Shandong University, Jinan 250012, China)
Journal Title:
Chinese Journal of Dermatology
Issue:
Volume 44, Issue 10, 2011
DOI:
10.3760/cma.j.issn.0412-4030.2011.10.004
Key Word:
Psoriasis;Matrix metalloproteinase 9;Gene;Han nationality;Shandong

Abstract: Objective To investigate the association of eIF4E and MMP-9 gene polymorphisms with psoriasis vulgaris in Han population of Shandong province.Methods A population based case-control association study was carried out in 188 patients with psoriasis vulgaris and 280 healthy human controls of Han nationality from Shandong province.Taqman SNP genotyping assay was performed to assess three SNPs,including rs4810482 and rs3918254 in MMP-9 gene and rs11723037 in eIF4E gene.Pairwise linkage disequilibrium was evaluated by using Haploview 4.2 software,and the frequencies of alleles and genotypes were analyzed by using Plink 1.07 software.Results The frequency of rs4810482 T allele was significantly lower in patients with psoriasis vulgaris than in the normal human controls(OR =1.49,95% CI:1.12-1.99,P < 0.01),and the significant difference still remained under recessive and dominant model.Bioinformatic analysis revealed that the rs4810482 altered the binding site of transcription factor,while no association was observed between psoriasis and either of the other two SNPs.Conclusions The SNP rs4810482 located at the upstream regulatory region of MMP-9 gene is significantly associated with psoriasis,hence,MMP-9 gene may be a susceptibility gene for psoriasis in Han population of Shandong province.

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