Association of HLA-A and -B alleles with syphilis in Shandong Han population

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Author:
JIANG Hong-wei(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
HOU Jian-ling(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
ZHENG Rong-tao(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
TIAN Hong-qing(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
LI Zhong-wei(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
LI Na(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
ZHAO Yi(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
LIU Dian-chang(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
LIU Bing(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
CHU Tong-sheng(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
LIU Hong(Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China)
Journal Title:
CHINESE JOURNAL OF DERMATOLOGY
Issue:
Volume 44, Issue 02, 2011
DOI:
10.3760/cma.j.issn.0412-4030.2011.02.018
Key Word:
Syphilis;HLA antigens;Alleles

Abstract: Objective To investigate the association of HLA-A and -B alleles with syphilis in Shandong Han population. Methods The allele frequencies of HLA-A and -B were detected in 205 patients with syphilis and 5844 normal human controls by PCR-sequence specific oligonucleotide probe (PCR-SSOP)method. Results The patients with syphilis showed a higher frequency of HLA-A*02, B*15, B*40 alleles(all P<0.01, Pc<0.05) and a lower frequency of HLA-A*26 allele (P= 0.003, Pc = 0.039) than the normal human controls did. There was an increased frequency of HLA-B*15 and B*40 alleles in patients with symptomatic syphilis (both P<0.01, Pc<0.05), as well as an elevated frequency of HLA-A*02, 11, 29, B*15 and 40 alleles (all P<0.01, Pc<0.05) and a decreased frequency of HLA-A*30 and 33 in patients with asymptomatic syphilis(P=0.002, 0.026, Pc=0.001, 0.013 respectively), compared with the normal human controls. The frequency of HLA-A*30 allele was significantly higher in patients with symptomatic syphilis than in those with asymptomatic syphilis (P = 0.001, Pc = 0.013). Conclusions There seems to be an association between HLA-A*02, B* 15 and B*40 alleles and syphilis, between HLA-A*30 allele and symptomic syphilis, and between HLA-A*02, 11 and 29 alleles and asymptom1atic syphilis, in Shandong Han population.

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