Relationship between Mycoplasma genitalium and mueopurulent cervicitis

( views:170, downloads:0 )
QI Mu-ge(Institute of Dermatology, Chinese Academy of Medical Sciences,Nanjing 210042, China)
JIANG Fa-xing()
WANG Qian-qiu(Institute of Dermatology, Chinese Academy of Medical Sciences,Nanjing 210042, China)
SU Xiao-hong(Institute of Dermatology, Chinese Academy of Medical Sciences,Nanjing 210042, China)
Journal Title:
Volume 41, Issue 05, 2008
Key Word:
Mycoplasma genitalium; Uterine cervicitis; Sexually transmitted diseases

Abstract: Objective To study the relationship between M. Genitalium and nongonococcal, non-chlamydial mucopurulent cervicitis. Methods A total of 226 patients with nongonococcal, nonchlamydial mu copurulent cervicitis and 118 healthy female volunteers were recruited in this study. Cervical samples were collected and M.genitalium was detected by PCR amplification of 16s rRNA and Pa genes. Information about socio-demographic characteristics, medical history, and sexual behaviors was gathered by questionnaire from both populations. Results The prevalence of M. Genitalium infection was 11.06% (25/226) in patients with mucpurulent cervicitis, 0,85% (1/118) in the healthy controls; the difference was significant between the two groups (x2 = 11.58, P < 0.001). Single variant analysis on the 226 patients showed that the preva-lence of M. Genitalium infection was 27.78%, 16.36%, 18.28% and 14.12% in patients with ectopic pregnancy history, cervical inflammation, pelvic organ tenderness, 10 or more polymorphonuclear leukocytes (PMNs)per oil immersion field in cervical discharge, respectively, significantly higher than that in patients without ectopic pregnancy history, cervical inflammation or pelvic organ tenderness, and those with less than 10 PMNs per oil immersion field in cervical discharge (9.62%, 6.03%, 6.02% and 1.79%, all P < 0.05). M.genitalium infection was also related to multiple sex partners and the presence of mucopurulent secretion in cervix (P < 0.001). Conclusion The prevalence of M.genitalium infection is higher in patients with non-gonococcal, nonchlamydial mucopurulent cervicitis attending STD clinic than that in normal population.

  • [1]Brunham RC,Paavonen J,Steven CE,et al.Mucopurulent cervici-tis-the ignored counterpart in women of urethritis in men.N Engl J Med,1984,311(1):1-6.
  • [2]Jensen JS,Borre MB,Dohn Birthe,et al.Detection of Mycoplasma genitalium by PCR Amplification of the 16S rRNA Gene.J Clin Microbiol,2003,41(1):261-266.
  • [3]Jensen JS,UIdum SA,Sondergard-Andersen J,et al.Polymerase chain reaction for detection of Mycoplasma genitalium in clini-cal samples.J Clin Microbiol,1991,29(1):46-50.
  • [4]Bradshaw CS,Tabrizi SN,Read TRH,et al.Etiologies of Nongono-coccal urethritis:bacteria,viruses,and the association with oro-genital exposure.J Infect Dis,2006,193(3):336-345.
  • [5]Manhart LE,Critchlow CW,Holmes KK,et al.Mucopurulent cer-vicitis and Mycoplasma genitalium.J Infect Dis,2003,187(4):650-657.
  • [6]Haggerty CL,Totten PA,Astete SG,et al.Mycoplasma genitalium among women with nongonococcal,nonchlamydial pelvic inflam-matory disease.Infect Dis Obstet Gynecol,2006,5:1-5.
  • [7]Andrsen B,Sokolowski I,Φstergaard L,et al.Mycoplasma geni-talium:prevalence and behavioural risk factors in the general population.Sex Transm Infect,2007,83(3):237-241.
  • [8]Manhart LE,Holmes KK,Hughes JP,et al.Mycoplasma genitalium among young adults in the United States:an emerging sexually transmitted infection.Am J Public Health,2007,97 (6):1118-1125.
  • [9]Uno M,Deguchi T,Komeda H,et al.Mycoplasma genitalium in the cervices of Japanese women.Sex Transm Dis,1997,24(5):284-286.
  • [10]Pepin J,Labbe AC,Khonde N,et al.Mycoplasma genitalium:an organism commonly associated with cervicitis among west African sex workers.Sex Transm Infect,2005,81 (1):67-72.
  • [11]黄澍杰,范宝剑,赵季文.广东江门地区性病患者中生殖支原体感染情况.疾病监测,2007,22(4):228-230.
  • [12]Cohen CR,Nosek M,Meier A,et al.Mycoplasma genitalium infection and persistence in a cohort of female sex workers in Nairobi,Kenya.Sex Transm Dis,2007,34(5):274-279.
WanfangData CO.,Ltd All Rights Reserved
About WanfangData | Contact US
Healthcare Department, Fuxing Road NO.15, Haidian District Beijing, 100038 P.R.China
Tel:+86-010-58882616 Fax:+86-010-58882615