Expression of transforming growth factor beta receptors, receptor-activated Smads and common-partner Smads in condylomata aeuminata

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Author:
SHANG Jin(Department of Dermatology, Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China)
HE Wei(Department of Dermatology, Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China)
YANG Jin-qing(Department of Dermatology, Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China)
LI Ying(Department of Dermatology, Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China)
HE Yun-zhi(Department of Dermatology, Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China)
WU Jun(Department of Dermatology, Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China)
WANG Ru-peng(Department of Dermatology, Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China)
REN Li(Department of Dermatology, Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China)
FU Qiu-hong(Department of Dermatology, Xinqiao Hospital,Third Military Medical University, Chongqing 400037, China)
Journal Title:
CHINESE JOURNAL OF DERMATOLOGY
Issue:
Volume 41, Issue 05, 2008
DOI:
Key Word:
Condylomata acuminata; Transforming growth factor beta; Receptors, transforminggrowth factor beta; Smad proteins; Signal transduction

Abstract: Objective To investigate the expressions of transforming growth factor beta receptors (TGF beta R), receptor-activated Smads and common-partner Smad in condylomata acuminata. Methods Tissue samples were collected from 20 patients with condylomata acuminata and 15 normal human controls.EliVisionTM plus immunohistochemical technique was used to detect the distribution and expression of TGF beta R Ⅰ , TGF beta R Ⅱ, Smad1/2/3, phosphorylated Smad2/3 and Smad4 in condylomata acuminata and normal control skin. Results Positive immunohistochemical staining for TGFbeta R Ⅰ , TGFbeta R Ⅱ,Smad1/2/3, p-Smad2/3 and Smad4 was detected in the epidermis of normal control skin. The intensity of im-munohistochemical staining was significantly lower for TGFbeta R Ⅰ , TGFbeta R Ⅱ, Smad1/2/3, p-Smad2/3and Smad4 in the epidermis of condylomata acuminata than in that of normal control skin (P < 0.05 or < 0.01). Conclusion The expressions of TGF beta R, receptor-activated Smads and common-partner Smad are decreased or absent in the epidermis of condylomata acuminata, which might interfere with TGF be-ta/Smad signaling and contribute to the development of epidermal hyperplasia in condylomata acuminata.

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