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Regulatory T cells in peripheral blood of patients with psoriasis
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0412-4030.2008.03.005
- Key Word:
- 银屑病;T淋巴细胞;CD4阳性T淋巴细胞
Abstract： 目的 检测不同类型银屑病患者外周血中调节性T细胞(Treg)的水平.方法 用流式细胞仪和单克隆荧光抗体检测20例寻常性银屑病、15例脓疱性银屑病和10例红皮病性银屑病患者外周血中CD4+CD25bright调节性T细胞百分率,对寻常性银屑病患者中的10例进行了CD4+CD25hi-intCD127low/-调节性T细胞百分率的检测.结果 红皮病性银屑病组CD4+CD25bright调节性T细胞比例高于其他组(P＜0.01);寻常性银屑病患者组CD4+CD25hi-intCD127low/-调节性T细胞在CD4+T细胞中比例为4.39%±0.84%,正常人对照组为3.83%±1.68%,两组进行Mann-Whitney U检验,差异无统计学意义(P＞0.05).结论 CD4+CD25bright调节性T细胞可能与红皮病性银屑病的发病有关.
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