You Position: Home > Paper
Expression of tazarotene induced gene-2 in lesions of patients with psoriasis vulgaris treated by narrow-band UVB alone or in combination with tazarotene
( views:334, downloads:24 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 3
- DOI:
- 10.3321/j.issn:0412-4030.2008.03.003
- Key Word:
- 银屑病;紫外线疗法;他扎罗汀;他扎罗汀诱导基因
Abstract： 目的 探讨NB-UVB联合他扎罗汀治疗寻常性银屑病的作用机制.方法 用免疫组化和原位杂交的方法检测NB-UVB和(或)他扎罗汀治疗前后银屑病皮损及未受累皮肤中TIG2蛋白和m RNA水平的变化.结果 治疗前,银屑病皮损中几乎无TIG2的表达,单用NB-UVB治疗2周后,角化不全的角质层和棘层上部可见TIG2轻度着色,治疗6周后,可见TIG2阳性表达于棘层上中部.两者联合治疗2周后,可见棘层全层和基底层着色,且在棘层上部着色重于中下部,6周后则表达于表皮全层,且表皮变薄.用NB-UVB和(或)他扎罗汀治疗后,TIG2阳性表达起始于角化不全的角质层和棘层上部至中下部,直至基底层,而他扎罗汀和NB-UVB联合应用后可加速此过程.结论 NB-UVB联合他扎罗汀协同治疗银屑病的机制可能与上调银屑病皮损中TIG2的表达有关.
- [1]郑焱,彭振辉,谭升顺,等.肝素结合表皮生长因子样生长因子在银屑病早期皮损中的意义[J].2003,(3).
- [2]陶娟,涂亚庭,熊芬,等.生存素在恶性黑素瘤中的表达及与VEGF和PCNA的关系[J].2007,(3).
- [3]Seo M,Kim Y,Lee MJ,etc.G Protein betagamma subunits augment UVB-induced apoptosis by stimulating the release of soluble heparin-binding epidermal growth factor from human keratinocytes.[J].2007,282(34).
- [4]Valdimarsson H,Johnston A,Gudjonsson JE,etc.Narrowband-UVB irradiation decreases the production of pro-inflammatory cytokines by stimulated T cells.[J].2005,297(1).
- [5]Patel S,Duvic M,Nagpal S,etc.Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin.[J].1997,109(1).
- [6]Wittamer V,Parmentier M,Mantovani A,etc.Role of ChemR23 in directing the migration of myeloid and plasmacytoid dendritic cells to lymphoid organs and inflamed skin.[J].2005,201(4).
- [7]David Communi,Marc Parmentier,Benjamin Bondue,etc.Neutrophil-Mediated Maturation of Chemerin:A Link between Innate and Adaptive Immunity[J].2005,175(1).
- [8]Martinsson H,Yhr M,Enerback C.Expression patterns of S100A7 (psoriasin) and S100A9 (calgranulin-B) in keratinocyte differentiation.[J].2005,14(3).
- [9]Wittamer V,Franssen JD,Vulcano M,etc.Specific Recruitment of Antigen-presenting Cells by Chemerin, a Novel Processed Ligand from Human Inflammatory Fluids.[J].2003,198(7).
- [10]Quan T,Wang HQ,Fisher GJ,etc.Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes.[J].2003,278(46).
- [11]Abu Amer-Y,Suva LJ,Chappel J,etc.1,25 dihydroxyvitamin D3 and dexamethasone induce the cyclooxygenase 1 gene in osteoclast-supporting stromal cells.[J].1999,74(4).
- [12]Zabel BA,Silverio AM,Butcher EC.Chemokine-like receptor 1 expression and chemerin-directed chemotaxis distinguish plasmacytoid from myeloid dendritic cells in human blood.[J].2005,174(1).