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Autoantigen epitopes in paraneoplastic pemphigus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0412-4030.2008.01.005
- Key Word:
- 天疱疮;自身抗原;斑蛋白类
Abstract： 目的 探讨副肿瘤性天疱疮的自身抗原表位.方法 运用重组融合蛋白免疫印迹实验、合成短肽酶联免疫吸附实验、竞争性酶联免疫吸附实验和斑点免疫印迹实验对副肿瘤性天疱疮的主要自身抗原-斑蛋白家族分子进行研究.结果 斑蛋白家族中周斑蛋白和包斑蛋白的L亚区是副肿瘤性天疱疮患者血清识别的主要抗原,其中包斑蛋白L亚区第1738～1757位氨基酸序列中存在着特异性抗原表位,可被多数副肿瘤性天疱疮血清识别.结论 包斑蛋白L亚区中存在着副肿瘤性天疱疮的特异性抗原表位.
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