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Minimum erythema dose determination in lupus erythematosus and its relationship with the state of illness
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF DERMATOLOGY
- Issue:
- 1
- DOI:
- 10.3321/j.issn:0412-4030.2008.01.003
- Key Word:
- 红斑狼疮;紫外线;红斑;测定
Abstract： 目的 探讨红斑狼疮患者的光生物学反应,了解红斑狼疮光敏感性与其病情的相关性.方法 采用日光紫外线模拟器对41例红斑狼疮患者进行UVA最小红斑量(UVA-MED)及UVB最小红斑量(UVB-MED)测定,同时评估测定结果与光敏感病史、临床病情及血清学指标之间的相关性.结果 41例红斑狼疮患者中,19例(46.34%)UVA-MED和/或UVB-MED降低.其中11例仅UVA-MED降低、5例仅UVB-MED降低,3例UVA-MED及UVB-MED同时降低.19例红斑狼疮患者接受2～4 MED的UVA或UVB照射后产生的红斑持续2周及以上仍未消退.光敏试验阳性组及阴性组抗Ro/SSA抗体的发生率分别为52.63%及9.09%(P=0.001),但光敏试验结果与光敏感病史、临床病情及其他血清学检查之间无明显相关性.结论 UVA及UVB可能同时参与红斑狼疮皮损的发生.MED的测定有助于红斑狼疮光敏感的判定.抗Ro/SSA抗体与红斑狼疮光敏感密切相关.
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